Individuals with sickle cell disease (SCD) present at the emergency department (ED) and are often admitted for hospitalization most commonly for vaso-occlusive pain episodes (VOEs). These episodes, also referred to as “pain crises” due to the intense pain experienced by patients, cause an acute arginine (Arg) deficiency. Arg supplementation has shown positive impacts on blood […]
Reistone Biopharma Co. Ltd. said both doses of the JAK1 inhibitor ivarmacitinib, tested against moderate to severe atopic dermatitis (AD) in a multinational phase III trial, met the study’s co-primary endpoints, delivering significant improvements on a common measure of disease severity vs. placebo. It’s the first National Class A new drug for AD that is […]